Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynes.
نویسندگان
چکیده
A general rhodium-catalyzed oxidative coupling reaction between internal alkynes and aryl aldimines is described. This process affords 3,4-disubstituted isoquinolines in good yield and high regioselectivity. Preliminary mechanistic studies suggest that the C-N bond formation arises from the reductive elimination of a rhodium(III) species.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 131 34 شماره
صفحات -
تاریخ انتشار 2009